Target: melanoma
نویسندگان
چکیده
منابع مشابه
Autophagy- An emerging target for melanoma therapy
Melanoma accounts for only 5% of all cancers but is the leading cause of skin cancer death due to its high metastatic potential. Patients with metastatic melanoma have a 10-year survival rate of less than 10%. While the clinical landscape for melanoma is evolving rapidly, lack of response to therapies, as well as resistance to therapy remain critical obstacles for treatment of this disease. In ...
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متن کاملKIT as a therapeutic target in metastatic melanoma.
CONTEXT Some melanomas arising from acral, mucosal, and chronically sun-damaged sites harbor activating mutations and amplification of the type III transmembrane receptor tyrosine kinase KIT. We explored the effects of KIT inhibition using imatinib mesylate in this molecular subset of disease. OBJECTIVE To assess clinical effects of imatinib mesylate in patients with melanoma harboring KIT al...
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ژورنال
عنوان ژورنال: Cancer
سال: 2013
ISSN: 0008-543X
DOI: 10.1002/cncr.28205